In testing adenosine for pulmonary artery hypertension, researchers have begun to make headway in treating one of the most dangerous diseases relating to high blood pressure.
The pulmonary arterial system consists of two arteries, the long right pulmonary artery and the shorter left pulmonary artery. They act together to transmit blood to the lungs.
Pulmonary artery hypertension, also known as PAH, is a condition where there is systemic and ongoing high blood pressure in the pulmonary artery.
The incidences of pulmonary artery hypertension is not very high in the general population, but when it does occur it can possibly be fatal – especially in its most severe form. In it’s lesser forms, it can still cause problems such as blocked or leaky heart valves and make it more difficult for the heart to pump blood to the lungs. Currently, there is no known cause for pulmonary artery hypertension and most experts attribute it to heredity.
To combat the problem, researchers have experimented with using Adenosine. Adenosine is a building block of DNA and a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule.
One of the really useful things that Adenosine can do is to prevent or inhibit body tissue damage. In the case of arterial hypertension, it can possibly prevent further damage from occurring in the pulmonary articles. In some animal studies, adenosine has even shown an ability to repair injured body tissue.
Ongoing trials are studying the usages of adenosine in regulating vascular tone in cases where pulmonary artery hypertension has already taken place. Of course, adenosine is not the only treatment being used to treat pulmonary hypertension, Researchers are also studying the effects of calcium channel blockers on pulmonary artery hypertension, both by itself and in combination with adenosine.
Drug Interactions and Adenosine
A side effect of adenosine is that it promotes sleep.
Caffeine can interfere with adenosine. Normally, adenosine binds to adenosine receptors in the brain. The effect is to slow down nerve cell activity which, in turn, can cause drowsiness. Caffeine, on the other hand, has the reverse effect on the brain. In effect, it nullifies the action of adenosine.
Guarana, green tea, and other drugs can interfere with adenosine as well. Your doctor can give you more information but, in general, be wary of taking drugs, herbs, medications, and the like that can interfere with adenosine.
Side Effects of Adenosine
Side effects of any medication are unique to the individuals who are taking them. The medication has triggered depression in some people. Many people have experienced drowsiness, but a few have reported feeling restless and having troubled sleep.
A very few patients have also mentioned feeling numb in their limbs for a short time after taking adenosine. Usually, however, the feeling does not last more than five minutes or so.
Depending on how the medication is administered, some feel that it leaves a lightly metallic taste in the mouth. This may be why some experience nausea as well.
Other Uses For Adenosine
Doctors will often prescribe various formulations of this chemical for treating a wide variety of conditions. Shingles, acute kidney failure, irregular heartbeat, cardiac stress tests, varicose vein treatment, tendonitis, nerve pain relief, and more.
Many surgeons also use it to control blood pressure during anesthesia and surgery.